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Paper | Regular issue | Vol 57, No. 3, 2002, pp.439-447
Published online, 1st January, 1970
DOI: 10.3987/COM-01-9398
A Structural and Conformational Study of 8-p-Nitrocinnamyl-3-propionyl-3,8-diazabicyclo[3.2.1]octane, Selective Agonist of μ-Opioid Receptors

Roberto Artali, Daniela Barlocco, Gabriella Bombieri,* and Fiorella Meneghetti

*Instituto di Chimica Farmaceutica e Tossicologica, Universita di Milano, Viale Abruzzi, 42, 20131 Milano, Italy

Abstract

8-p-Nitrocinnamyl-3-propionyl-3,8-diazabicyclo[3.2.1]octane (2b) and its isomer (1b), having the nitrogen substituents exchanged, have been compared by X-Ray structural analysis. The different orientation of the cinnamyl chain in the two derivatives has been discussed and related to the pharmacological properties.