HETEROCYCLES

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■ Ring Closing Metathesis Reaction of Dienes with Acrylate Moiety Leading to 5- to 7-Membered Lactones and Cyclization to 14-Membered Rings

Katsuyuki Nakashima, Masashi Imoto, Takuo Miki, Takahiro Miyake, Norihiro Fujisaki, Shiori Fukunaga, Reiko Mizutani, Masakazu Sono, and Motoo Tori*

*Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima, 770-8514, Japan

Abstract

Dienes with acrylate moiety have been subjected to olefin metathesis reactions using (PCy₃)₂Cl₂Ru=CHPh (1) and (PCy₃)Cl₂[H₂imid(Mes)₂]Ru=CHPh (2). 5- to 7-Membered α,β-unsaturated lactones were obtained in good yields. Formation of 14-membered compounds was attempted using different substrates.