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Paper | Regular issue | Vol 57, No. 8, 2002, pp.1423-1432
Published online, 1st January, 1970
DOI: 10.3987/COM-02-9500
Microwave Assisted Synthesis of New Benzimidazoles

Yves Njoya, Narimène Boufatah, Armand Gellis, Pascal Rathelot, Michel P. Crozet, and Patrice Vanelle*

*Laboratoire de Chimie Organique, Faculté de Pharmacie, Université de la Méditerranée, 27, Boulevard Jean Moulin, 13385 Marseille Cedex 05, France

Abstract

New potentially bioactive and highly functionalized benzimidazoles were synthesized by using microwave irradiation methodology in multi-steps: construction of benzimidazole ring, N-methylation and electron transfer C-alkylation (followed by base-promoted nitrous acid elimination) or S-alkylation.