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Note | Regular issue | Vol 57, No. 10, 2002, pp.1881-1890
Published online, 1st January, 1970
DOI: 10.3987/COM-02-9524
Improved Synthesis of N-Substituted 2,3-Pyridinedicarboximides with Microwave Irradiation

María M. Blanco, Gustavo J. Levin, Celia B. Schapira, and Isabel A. Perillo*

*Departamento de Química Orgánica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 (1113) Buenos Aires, Argentina

Abstract

The microwave-induced synthesis of N-substituted 2,3-pyridinedicarboximides (1) by means of two different approaches is presented. One involves direct N-alkylation of quinolinimide (2) (Method A) and the other, dehydrative condensation of quinolinic anhydride (4) and amines (Method B). Reactions resulted highly accelerated, with improved yields in relation to those obtained by conventional heating. The scope and limitations of each method and its variants are discussed.