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Note | Regular issue | Vol 57, No. 8, 2002, pp.1501-1506
Published online, 1st January, 1970
DOI: 10.3987/COM-02-9525
Synthesis of 1,4-Benzodiazepine-2,5-dione Derivatives

Tong-Ing Ho,* Wen-Shiong Chen, Chi-Wei Hsu, Yeun-Min Tsai, and Jim-Min Fang

*Department of Chemistry, National Taiwan University, Roosevelt Road Section 4, Taipei 106, Taiwan, R.O.C.

Abstract

A synthesis of a series of 1,4-benzodiazepine-2,5-dione derivatives with a carboxy group at the 3-position is realized in good yields by using methyl malonylchloride as a key reagent and intramolecular nucleophilic substitution as ring closure reaction.