HETEROCYCLES

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

■ Synthesis of Heterocyclic γ-Amino-α,β-unsaturated Acid Derivatives and Peptide-Heterocycle Hybrids

Antonio Salgado, Enrique Mann, Francisco Sánchez-Sancho, and Bernardo Herradón*

*Instituto de Química Orgánica General, C. S. I. C., Calle Juan de Cierva, 3, 28006 Madrid, Spain

Abstract

The syntheses of the γ-amino-α,β-unsaturated esters [(R)-4, (S)-5, and (±)-6] are reported. The methodology for the preparation of these triannular heterocycles involves two synthetic sequences from N-substituted amino alcohols: a ‘one-pot’ sequential Swern oxidation-Wittig reaction and an intramolecular Heck reaction. The γ-amino-α,β-unsaturated ester [(R)-4] has been used for the synthesis of the peptide-heterocycle hybrids (19-21).