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Note | Regular issue | Vol 60, No. 1, 2003, pp.151-157
Published online, 15th November, 2002
DOI: 10.3987/COM-02-9606
Phosphodiesterase Inhibitory Coumarinolignoids from Duranta repens

Kiran Iqbal, Itrat Anis, Naveen Muhktar, Abdul Malik,* Naheed Fatima, and Muhammad Iqbal Chaudhary

*International Centre for Chemical Sciences, H. E. J. Research Institute of Chemistry, University of Karachi, Pakistan

Abstract

Durantins A-C (1-3), new coumarinolignoids together with three known compounds cleomiscosins A (4), 6,7,8-trimethoxycoumarin (5) and 5,4’-dihydroxy-3,6,7-trimethoxyflavone (6) have been isolated from a CHCl3 soluble fraction of Duranta repens. Their structures were assigned on the basis of spectral studies. Compounds (1, 3 and 4) showed inhibitory activity against phosphodiesterase enzyme.