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Paper | Regular issue | Vol 60, No. 2, 2003, pp.337-344
Published online, 9th December, 2002
DOI: 10.3987/COM-02-9638
Synthesis of Thieno[2,3-b]pyrazines via an Acylation - Deacylation Process of 3,4-Dihydro Precursors

Thomas Erker,* Karin Trinkl, and Franz Pertlik

*Institute of Pharmaceutical Chemistry, University of Vienna, Althanstraße 14, A-1090 Vienna, Austria

Abstract

In the first step 3, 4-dihydrothieno[2,3-b]pyrazines (1, 2 and 4) were N-acylated by the acyl chlorides followed by a deacylation process mediated by triethylamine to give thieno[2,3-b]pyrazines . In a final rection the excess of the appropriate acyl chlorides react with the free hydroxy residue to afford compounds (15, 16 or 17).