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Note | Regular issue | Vol 60, No. 1, 2003, pp.177-182
Published online, 25th November, 2002
DOI: 10.3987/COM-02-9641
■ Anticoccidial Activity of Some Azacyclo Organoborinates

Hitoshi Tabuchi, Harumoto Kawaguchi, Hisashi Taniguchi, Hideyuki Imazaki, and Yoshio Hayase*

*Aburahi Laboratories, Shionogi & Co. Ltd., Gotanda, Koka-cho, Koka-gun, Shiga 520-3423, Japan

Abstract

A series of new azacyclo organoborinates derivatives of piperidinyl and pyridinyl alcohols with anticoccidial activity in vivo assay system in battery trials are described. Parameters of anticoccidial efficacy that were evaluated were body weight, lesion scores and number of oocysts. Among them, di(4-chlorophenyl)(2-piperidinylmethoxy-O,N)boron, and di(3-trifluoromethyl-phenyl)(2-pyridinylethoxy-O,N)boron showed good anticoccidial activity against both of the important parasite, Eimeria tenella and Eimeria acervulina