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Note | Regular issue | Vol 60, No. 2, 2003, pp.413-418
Published online, 9th December, 2002
DOI: 10.3987/COM-02-9659
The One-Pot Conversion of Pyrimidinone Derivatives into Substituted Pyrimidines Using Diphenylphosphinic Chloride under a Mild Condition

Ken-ichi Tanji, Takeshi Yokoi, and Osamu Sugimoto*

*Laboratory of Organic Chemistry, School of Food and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan

Abstract

Pyrimidinone derivatives reacted with diphenylphosphinic chloride followed by addition of nucleophiles to afford substituted pyrimidine derivatives at a mild temperature (20-66 °C).