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Note | Regular issue | Vol 60, No. 4, 2003, pp.933-938
Published online, 4th February, 2003
DOI: 10.3987/COM-02-9688
Ent-Kaurane Diterpenoids from Isodon rubescens var. lushiensis

Quanbin Han, Shenghong Li, Liyan Peng, and Handong Sun*

*State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, China

Abstract

Three new 6,7-seco-6,19:6,20-diepoxy-1α,7-olide-ent-kaurane diterpenoids, ludongnins C-E (1-3), along with six known analogs, macrocalyxoformins A (4) and B (5), sculponeatins A (6) and B (7), and ludongnins A (8) and B (9), were isolated from Isodon rubescens var. lushiensis. The structures of the new compounds were determined on the basis of the spectroscopic evidences. Compound (5) exhibited significant inhibitory activities against the Bcap37 and K562 cell lines with IC50 = 0.82 and 0.62 μg/mL, respectively.