Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,320 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Special issue | Vol 59, No. 2, 2003, pp.685-690
Published online, 1st January, 1970
DOI: 10.3987/COM-02-S78
Preparation of 7-Substituted 4,5-Dihydro-7H-Pyrano[3,4-c]isoxazole Derivatives

Koji Yamada, Fumio Yamada, and Masanori Somei*

*Faculty of Pharmaceutical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan


An easy approach to 7-substituted 4,5-dihydro-7H-pyrano[3,4-c]isoxazole derivatives (3a-b and 6a-d) is described by the reaction of 2-aryl substituted 1-nitro-3-oxa-6-heptynes (2, 5a and 5b) with n-BuLi, followed by treatment with acetic anhydride.