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Paper | Regular issue | Vol 60, No. 5, 2003, pp.1147-1159
Published online, 24th March, 2003
DOI: 10.3987/COM-03-9719
Oxovanadium Complexes of N-Substituted 3-Hydroxy-2-methyl-4(1H)-pyridinones: Synthesis, Spectroscopic Characterization, and the Insulin-mimetic Activity

Akira Katoh,* Kazutoshi Taguchi, Ryota Saito, Yae Fujisawa, Toshikazu Takino, and Hiromu Sakurai

*Department of Applid Chemistry, Faculty of Engineering, Seikei University, Musashino, Tokyo 180-8633, Japan

Abstract

Five kinds of N-substituted 3-hydroxy-2-methyl-4(1H)-pyridinones, and two kinds of tetradentate ligands, N,N ’-[bis(3-hydroxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)hexanoyl- and -octanoyl]-1,5-diamino-3-oxapentanes, were syn-thesized. Treatment of these ligands with VO(acac)2 in CH3OH exclusively gave CH3O-coordinated oxovanadium(V) complexes. On the other hand, treatment with VOSO4 in H2O at around pH 10 afforded oxovanadium(IV) complexes. On the basis of the inhibitory effect of oxovanadium(IV) complexes on free fatty acid (FFA) release from rat adipocytes treated with epinephrine in the presence of 0.1% glucose in vitro, it was revealed that some of oxovanadium(IV) complexes show the insulin-mimetic activity.