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Paper | Regular issue | Vol 60, No. 6, 2003, pp.1359-1366
Published online, 7th April, 2003
DOI: 10.3987/COM-03-9744
Synthesis and COX-2 Inhibitory Activities of Rutaecarpine Homologues

Hyeun Wook Chang, Seung Ill Kim, Hejin Jung, and Yurngdong Jahng*

*College of Pharmacy, Yeungnam University, Kyongsan 712-749, Korea

Abstract

Homologous series of rutaecarpine were prepared by structurally modifying the C-ring and were evaluated their inhibitory activities on COX-2. The inhibitory activity on COX-2 increased with the increase of methylene unit while the selectivity on COX-2 over COX-1 decreased to lead a loss in trimethylene bridged system.