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Note | Regular issue | Vol 60, No. 10, 2003, pp.2287-2292
Published online, 18th August, 2003
DOI: 10.3987/COM-03-9769
One-Pot Synthesis of 1,2,4-Oxadiazoles Mediated by Microwave Irradiation under Solvent-free Condition

Babak Kaboudin* and Kian Navaee

*Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Gava Zang, Zanjan 45195-159, Iran

Abstract

Microwave-assisted synthesis of 1,2,4-oxadiazoles of amidoximes under solvent free conditions was found to be an efficient method for one-pot synthesis of 1,2,4-oxadiazole derivatives from amidoximes and acyl chlorides. This method is an easy, rapid, and high-yielding reaction for the synthesis of 1,2,4-oxadiazoles.