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Communication | Regular issue | Vol 60, No. 7, 2003, pp.1567-1572
Published online, 9th June, 2003
DOI: 10.3987/COM-03-9783
Useful Synthesis of the Longer Array Oxazole Rings for Telomestatin

Nobuaki Endoh, Katumasa Tsuboi, Riyong Kim, Yasuchika Yonezawa, and Chung-gi Shin*

*Laboratory of Organic Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686, Japan

Abstract

The convenient syntheses of the precursors of the constituting Fragments A, B, A-B, and its macrocyclic compounds for telomestatin, which exhibits strong antitumor activity, were first achieved.