HETEROCYCLES

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

■ Diospolysaponin A, a New Polyoxygenated Spirostanol Saponin from the Tubers of Dioscorea polygonoides

Jaime Niño Osorio, Oscar M. Mosquera Martinez, Yaned M. Correa Navarro, Yoshihiro Mimaki,* Hiroshi Sakagami, and Yutaka Sashida

*Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan

Abstract

Chemical investigation of the tubers of Dioscorea polygonoides has resulted in the isolation of a novel polyoxygenated spirostanol saponin, named diospolysaponin A (1), along with a known spirostanol saponin (2). The structure of 1 was determined on the basis of spectroscopic analysis and by enzymatic hydrolysis followed by chromatographic and spectroscopic studies to be (23S,25R)-12α,14α,17α,23-tetrahydroxyspirost-5-en-3β-yl O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside. The cytotoxic activity of 1 and 2 and their aglycons against HSC-2 cells is briefly presented.