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Note | Regular issue | Vol 60, No. 7, 2003, pp.1709-1715
Published online, 2nd June, 2003
DOI: 10.3987/COM-03-9797
Diospolysaponin A, a New Polyoxygenated Spirostanol Saponin from the Tubers of Dioscorea polygonoides

Jaime Niño Osorio, Oscar M. Mosquera Martinez, Yaned M. Correa Navarro, Yoshihiro Mimaki,* Hiroshi Sakagami, and Yutaka Sashida

*Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan


Chemical investigation of the tubers of Dioscorea polygonoides has resulted in the isolation of a novel polyoxygenated spirostanol saponin, named diospolysaponin A (1), along with a known spirostanol saponin (2). The structure of 1 was determined on the basis of spectroscopic analysis and by enzymatic hydrolysis followed by chromatographic and spectroscopic studies to be (23S,25R)-12α,14α,17α,23-tetrahydroxyspirost-5-en-3β-yl O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside. The cytotoxic activity of 1 and 2 and their aglycons against HSC-2 cells is briefly presented.