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Paper | Regular issue | Vol 60, No. 9, 2003, pp.2057-2063
Published online, 4th August, 2003
DOI: 10.3987/COM-03-9815
Enantioselective Synthesis of Mono- and Disubstituted 3,6-Dihydro-2H-pyrans and 5,6-Dihydropyran-2-ones

Irene Izzo,* Pasquale Del Gaudio, Carmela Della Monica, Maria Squitieri, and Francesco De Riccardis*

*Department of Chemistry, University of Salerno, Via S. Allende I-84081 Baronissi(SA), Italy


An enantioselective synthesis of mono- and disubstituted 3,6-dihydro-2H-pyrans and 5,6-dihydropyran-2-ones was achieved via ring-closing olefin metathesis, employing Grubb’s catalyst, and starting from ready available chiral building blocks.