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Note | Regular issue | Vol 60, No. 10, 2003, pp.2293-2303
Published online, 18th August, 2003
DOI: 10.3987/COM-03-9841
Synthesis of Rigid Bicycloheterocyclic Scaffolds from Vince’s Lactam (Enzymatic Resolution of Vince’s Lactam)

Mukund K. Gurjar,* Smritilekha Bera, Rohini R. Joshi, and Ramesh A. Joshi

*National Chemical Laboratory, Pune 411 008, India

Abstract

Vince’s lactam, on oxidative cleavage and reduction, produced the 3,5-dihydroxymethylpyrrolidin-2-one derivative. This precursor has been utilized in intramolecular cyclization reactions to design some unique diaza-, oxaaza-, and thiaaza-bicyclic molecules as potential scaffolds in combinatorial chemistry.