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■ Two New Bicoumarins from Clausena excavata

Yuko Takemura, Kinuko Kanao, Asami Konoshima, Motoharu Ju-ichi,* Chihiro Ito, Hiroshi Furukawa, Harukuni Tokuda, and Hoyoku Nishino

*Faculty of Pharmacy, Meijo University, 150 Yagoto, Tempaku-ku, Nagoya, Aichi 468-8503, Japan

Abstract

Two novel type bicoumarins, named cladimarins A (1) and B (4), were isolated from the branch of Clausena excavata (Rutaceae) collected in Indonesia. The structures were elucidated on the basis of spectroscopical data especially by using HMBC method. Naturally occurring bicoumarin, connected two coumarin moieties by acetal ring as in 1 and by ester bond as in 4, is rare type. Inhibitory effects of new bicoumarins on EBV-EA activation induced by TPA in Raji cells were also demonstrated.