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Note | Regular issue | Vol 63, No. 2, 2004, pp.367-371
Published online, 8th December, 2003
DOI: 10.3987/COM-03-9923
An Efficient Synthesis of 6,6-Dimethyl-2-(4-nitrophenyl)-1-(R-phenyl)-4,5,6,7-tetrahydro-1H-4-indolones Using a Solid Sulfated Zirconia as Catalyst

Guillermo Negrón,* Deyanira Ángeles, Leticia Lomas, Ángeles Martínez, Manuel Ramírez, and Roberto Marínez

*Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitatria, CoyoacÁn 04510, Mexico


Sulfated zirconium has been found to be an excellent substitute for conventional acids in the tetrahydroindolone derivatives synthesis, resulting in milder reaction conditions, bringing down reaction temperature and formulating more efficient isolation and purification procedure.