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■ Synthesis and Characterization of Potential Photolabeling Probes for Studying the Antiviral Mechanisms of EICAR

Qiongyou Wu, Jinqiao Wan, Yi Xia, Jiehua Zhou, Fanqi Qu, and Ling Peng*

*AFMB CNRS UMR 6098, Département de Chimie, Université Aix-Marseille II, 163, avenue de Luminy, 13288 Marseille, France

Abstract

The designed photolabeling probes: 5-diazonium-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide (1) and 5-azido-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide (2) were synthesized via a short and convenient synthetic route, namely by diazotizing AICAR and subsequently performing substitution with NaN₃. Although 1 was not stable even at low temperatures, 2 showed a rapid and clean photochemical reaction, which suggests that it may be a valuable tool for use in photolabeling studies.