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Paper | Regular issue | Vol 63, No. 2, 2004, pp.347-357
Published online, 26th December, 2003
DOI: 10.3987/COM-03-9970
New Cytotoxic Norditerpene Dilactones from Leaves of Podocarpus macrophyllus var. maki

Hyun-Sun Park, Noriyuki Kai, Haruhiko Fukaya, Yutaka Aoyagi, and Koichi Takeya*

*School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan

Abstract

Four new nor- and bisnorditerpene dilactones, rakanmakilactones G(1), H-J (3-5), one new norditerpene dilactone apioside (2), and one new totarane diterpene (6) were isolated from a MeOH extract of the leaves of Podocarpus macrophyllus D. Don var. maki Endl. of the family Podocarpaceae. The structures of 1-6 were established by spectroscopic studies, including 1D and 2D NMR spectral analysis, and single-crystal X-Ray crystallographic analysis. Those rakanmakilactones from this plant were found to have a cytotoxic effect on P388 murine leukemia cells.