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Note | Regular issue | Vol 63, No. 3, 2004, pp.707-713
Published online, 16th January, 2004
DOI: 10.3987/COM-03-9975
A Convenient Synthesis of Trifluoromethylpyridazines from 3-Hydrazono-1,1,1-trifluoroalkan-2-ones

Yasuhiro Kamitori* and Tomoko Sekiyama

*Department of Chemical Science and Engineering, Faculty of Engineering, Kobe University, Kobe 657-8501, Japan


3-Hydrazono-1,1,1-trifluoroalkan-2-ones readily obtained from aldehyde dialkylhydrazones reacted with acetylacetone to afford the corresponding 4-acetyl-3-methyl-5-trifluoromethylpyrizazines in good yields. The reaction with ethyl acetoacetate also gave the corresponding pyridazines. These reactions proceeded successfully in the absence of any catalyst.