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Note | Regular issue | Vol 63, No. 4, 2004, pp.879-884
Published online, 6th February, 2004
DOI: 10.3987/COM-03-9994
A New Pterocarpan from Erythrina fusca

Pranorm Khaomek, Nijsiri Ruangrungsi,* Ekarin Saifah, Nongluksna Sriubolmas, Chikara Ichino, Hiroaki Kiyohara, and Haruki Yamada

*Faculty of Pharmaceutical Sciences, Chulalonghorn University, Bangkok 10330, Thailand

Abstract

A new pterocarpan, 3-hydroxy-10-(3-hydroxy-3-methylbutyl)-9-methoxypterocarpan (1), together with seven known compounds, sandwicensin (2), erythrisenegalone (3), citflavanone (4), liquiritigenin (5), lonchocarpol A (6), lupinifolin (7) and 8-prenyldaidzein (8), were isolated from the stem bark of Erythrina fusca. The structure of 1 was determined on the basis of spectroscopic analyses. Among these compounds, lonchocarpol A (6) exhibited strongly antibacterial activities in vitro against Staphylococcus aureus, Bacillus subtilis and Enterococcus faecalis. Compounds (2, 3, 6 and 7) exhibited weakly antimycobacterial activity with minimum concentrations (MICs) of 100, 50, 50 and 25 μg/mL, respectively.