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Paper | Regular issue | Vol 63, No. 5, 2004, pp.1045-1056
Published online, 8th March, 2004
DOI: 10.3987/COM-03-9999
Synthesis of 3-Ferrocenyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazoles

Elena Klimova, Tatiana Klimova,* Teresa Ramírez Apan, Antonio Neito Camacho, Rafael Moreno Esparza, Carlos Damian Zea, and Marcos Martínez García

*Faculty of Chemistry, National Autonomous University of Mexico, Cd. Universitaria, Coyoacan, C.P. 04510, Mexico

Abstract

The reactions of E-2-ferrocenylmethylidenetetralones with hydrazine proceed diastereoselectively, forming the cis isomers of diazatricycles in high yields. The studies of the anti-inflammatory activity of E-2-ferrocenylmethylidenetetralones and N-acetylindazoles showed a moderate activity in a TPA model. The structure of 2-acetyl-3-ferrocenyl-6-methoxy- 3,3a,4,5-tetrahydro-2H-benzo[g]indazole was confirmed by X-Ray diffraction analysis.