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Communication | Special issue | Vol 62, No. 1, 2004, pp.131-135
Published online, 14th October, 2003
DOI: 10.3987/COM-03-S(P)20
Solid-Phase Synthesis of Cyclic Glycopeptides Related to Mannopeptimycin Derivatives

Ting-Zhong Wang,* Karen L. Wheless, Alan G. Sutherland, and Russell G. Dushin

*Chemical Development, Wyeth Research, Middletown Rd. Pearl River, NY 10965, U.S.A.

Abstract

The mannopeptimycins comprise a novel series of glycopeptide antibiotics that display activity against susceptible and resistant forms of gram-positive bacteria. Low isolated yields of these products from fermentation make the synthesis of easily accessible analogs attractive. A simplified hexapeptide is synthesized using a combination of solid-phase and solution-phase techniques.