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Communication | Special issue | Vol 61, No. 1, 2003, pp.93-96
Published online, 11th August, 2003
DOI: 10.3987/COM-03-S47
Synthesis of 2-Substituted Benzimidazoles by Reaction of o-Phenylenediamine with Aldehydes in the Presence of Sc(OTf)3

Kazuhiro Nagata, Takashi Itoh, Hiroyuki Ishikawa, and Akio Ohsawa*

*School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan

Abstract

2-Substituted benzimidazoles were synthesised under mild conditions by reaction of o-phenylenediamine with aldehydes in the presence of Sc(OTf)3 as a Lewis acid catalyst.