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Paper | Regular issue | Vol 63, No. 5, 2004, pp.1123-1129
Published online, 30th March, 2004
DOI: 10.3987/COM-04-10037
Gliocladins A - C and Glioperazine ; Cytotoxic Dioxo- or Trioxopiperazine Metabolites from a Gliocladium Sp. Separated from a Sea Hare

Yoshihide Usami,* Junko Yamaguchi, and Atsushi Numata

*Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan

Abstract

New dioxo- or trioxopiperazine metabolites named gliocladins A-C (1 - 3) and glioperazine (4) have been isolated from a strain of Gliocladium sp., originally separated from the sea hare. Their structures have been elucidated by spectroscopic analyses using various NMR spectroscopic techniques. Structurally unique trioxopiperazine (3) exhibited significant cytotoxicity against cultured P388 cells.