Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,320 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 63, No. 5, 2004, pp.1131-1142
Published online, 26th March, 2004
DOI: 10.3987/COM-04-10041
Synthesis of Isotope Labeled Me(3a)-13C-Physostigmine and Debromoflustramine B

Martha S. Morales-Ríos,* Norma F. Santos-Sánchez, Yolanda Mora-Pérez, and Pedro Joseph-Nathan

*Departamento de Química, Centro de Investigación y de Estudios Avanzados, I.P.N, Apartado 14-740, México, D.F., 07000, Mexico

Abstract

A versatile and concise synthetic route for the synthesis of selectively functionalized pyrrolo[2,3-b]indole alkaloid analogues has been developed starting from 3-indolylacetonitriles. Employing this route, physostigmine with 13C-enrichment at Me(3a) (99 atom% 13C) and debromoflustramine B have been prepared.