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Note | Regular issue | Vol 63, No. 7, 2004, pp.1613-1618
Published online, 23rd April, 2004
DOI: 10.3987/COM-04-10045
Microwave-assisted One-Pot Synthesis of Tri-substituted Imidazoles on Solid Support

Yu Xu, Li-Feng Wan, Hojatollah Salehi, Wei Deng, and Qing-Xiang Guo*

*Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei 230026, China


A solvent-free microwave-assisted synthesis of trisubstituted imidazoles is reported. The imidazoles are produced by the condensation of α-hydroxyketone with an aldehyde over silica gel or alumina impregnated with ammonium acetate as the solid support in short time with good yields. An air oxidation mechanism is proposed, and this clean air oxidation considerably reduces the cost of imidazole synthesis.