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Note | Regular issue | Vol 63, No. 8, 2004, pp.1883-1890
Published online, 11th June, 2004
DOI: 10.3987/COM-04-10092
Synthesis of Novel 5H-Pyrazolo[4,3-c]quinolines

Olexiy V. Silin, Timur I. Savchenko, Sergiy M. Kovalenko, Viktor M. Nikitchenko, and Alexandre V. Ivachtchenko*

*Chemical Diversity Labs, Inc., Sorrento Valley Rd., Suite 5, San Diego, California 11558, U.S.A.

Abstract

A convenient synthesis of 3-aryl-5H-pyrazolo[4,3-c]quinolines is described. The key reactions include alkylation of 3-aroyl-1H-quinolin-4-ones with alkyl halides in DMF in the presence of sodium hydride, followed by hydrazine-mediated cyclization of the alkylated products in acetic acid.