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Paper | Regular issue | Vol 63, No. 8, 2004, pp.1829-1838
Published online, 11th June, 2004
DOI: 10.3987/COM-04-10108
Synthesis of Functionalized 1H-Pyrazolo[4,3-e][1,2,4]triazines and Their Fused Derivatives via Ipso-Substitution of Methylsulfonyl Group with O-, N-, S- and C-Nucleophiles

Mariusz Mojzych and Andrzej Rykowski *

*Institute of Chemistry, University of Podlasie, ul. 3-go Maja 54, 08-110 Siedlce, Poland

Abstract

Ipso-substitution reaction of 3-methyl-5-methylsulfonyl-1-phenyl-1H-pyrazolo[4,3-e][1,2,4]triazine (4) with a range of C-, N-, O- and S-nucleophiles afforded the corresponding substitution products (5a-m) in high yields. The reaction of 5-hydrazino compound (5m) with carboxylic acids furnished 1H-pyrazolo[4,3-e]-1,2,4-triazolo[4,3-b][1,2,4]triazines (8a) and (8b).