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■ SnCl₄-Promoted Ethenylation Reaction of Hydroxylated Heteroarenes

Kensuke Akamatsu, Ryo Amemiya, and Masahiko Yamaguchi*

*Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Sendai 980-8578, Japan

Abstract

Reaction of hydroxylated heteroarenes and acetylene in the presence of SnCl₄ and Bu₃N (or Et₃N) gives the corresponding ethenylated arenes. The reaction takes place at the neighboring position of the hydroxy group, and is applicable to quinolines, an isoquinoline, pyridines, and N-trifluoromethanesulfonylated indoles provided that the optimized conditions for the ethenylation and workup are employed.