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Note | Regular issue | Vol 63, No. 9, 2004, pp.2101-2109
Published online, 6th August, 2004
DOI: 10.3987/COM-04-10157
Two Sesquiterpene-Coumarins from the Roots of Ferula marmarica

Mohamed H. Abd El-Razek, Fang-Rong Chang, Chih-Chuang Liaw, Mahmoud I. Nassar, Hui-Chi Huang, Yung-Husan Chen, Yu-Liang Yang, and Yang-Chang Wu*

*Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C.


Two new sesquiterpene-coumarin conjugates designated foetidin acetate and foetidone were isolated from the roots of Ferula marmarica. The structures of the sesquiterpene-coumarins have been fully characterized by spectroscopic methods, among which foetidin acetate was confirmed by single-crystal X-Ray crystallography. Absolute configuration of both new compounds was established by CD.