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Note | Regular issue | Vol 63, No. 9, 2004, pp.2111-2122
Published online, 6th August, 2004
DOI: 10.3987/COM-04-10162
Synthesis of Mycalamide Analogs

Shunya Takahashi, Akihiro Okada, and Tadashi Nakata*

*Department of Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan

Abstract

Several new artificial analogs (3-6) of mycalamide A (1), a potent antiviral and antitumor agent, were synthesized through a coupling reaction of a bicyclic amine (19) with two tetrahydropyrancarboxylic acids (15) and (18), and their cytotoxicity and antiviral activity were tested.