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Paper | Regular issue | Vol 63, No. 12, 2004, pp.2727-2734
Published online, 8th October, 2004
DOI: 10.3987/COM-04-10193
Synthesis of New Potential HIV-1 Integrase Inhibitors

Stefania Ferro, Angela Rao, Maria Zappalà, Alba Chimirri, Maria Letizia Barreca, Myriam Witvrouw, Zeger Debyser, and Pietro Monforte*

*Dipartimento Farmaco-Chimico, Università di Messina, Viale Annunziata, 98168 Messina, Italy

Abstract

A synthesis of some 1,2-(hetero)arylsubstituted ethanone and 1,3-(hetero)arylsubstituted 3-hydroxypropenone derivatives, designed as potential HIV-1 integrase inhibitors, is reported. The microwave-assisted synthesis was applied in several reactions achieving reductions in reaction times and high yields. All compounds prepared were tested to explore their potential anti-HIV activity.