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Paper | Regular issue | Vol 63, No. 12, 2004, pp.2735-2746
Published online, 8th October, 2004
DOI: 10.3987/COM-04-10206
Useful Synthesis of 2,3,6-Tri- and 2,3,5,6-Tetrasubstituted Pyridine Derivatives from Aspartic Acid

Yasuchika Yonezawa, Akihito Konn, and Chung-gi Shin*

*Departmnet of Applied Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686, Japan


New synthetic methods for 2,3,6-tri- and 2,3,5,6-tetrasubstituted pyridine skeletons, which are the essential main central segments of thiostrepton-type macrocyclic antibiotics, were developed from L-α-aspartic acid (Asp) via the Asp-derived α-dehydroamino acid ester.