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Paper | Regular issue | Vol 65, No. 4, 2005, pp.767-773
Published online, 8th February, 2005
DOI: 10.3987/COM-04-10257
A One-Pot Synthesis of 3,4-Dihydropyrimidin-2-(1H)-ones from Primary Alcohols Promoted by Bi(NO3)3·5H2O in Two Different Media: Organic Solvent and Ionic Liquid

Ahmad R. Khosropour,* Mohammd M. Khodaei,* Mojtaba Beygzadeh, and Mahbubeh Jokar

*Department of Chemistry, Faculty of Science, Razi University, Kermanshah 67149, Iran

Abstract

A new, simple and efficient procedure for the one-pot conversion of alcohols instead of aldehydes to the corresponding 3,4-dihydropyrimidin-2(1H)- ones (DHPMs) with Bi(NO3)3.5H2O as a commercially available, inexpensive, stable and non-toxic reagent in two media, acetonitrile (as an organic solvent) and tetrabutylammonium bromide (as an ionic liquid) is described. This one-pot oxidation-cyclocondensation reaction is performed without isolation of any intermediate (aldehyde) and thus reducing time, saving energy and raw materials. On the other hand treatment of primary alcohols with this new one-pot method produce the dehydropyrimidinones in higher yields than those are obtained in the traditional method.