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■ Four New Coumarin Glucosides from the Roots of Heracleum rapula

Weilie Xiao, Shenghong Li, Yunheng Shen, Xiaoli Li, and Handong Sun*

*State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Heilongtan, Kunming 650204, Yunnan, China

Abstract

Four new coumarin glucosides, 7-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl]demethylsuberosin (1), 8-O-[β-D-apiofuranosyl-(1→6)-β-D-glucopyranosyl]-8-hydroxybergapten (2), 8-O-[β-D-apiofuranosyl-(1→6)-β-D-glucopyranosyl]xanthotoxol (3), and 5-O-[β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl]-8-hydroxybergaptol (4), were isolated from the roots of Heracleum rapula. The structures of these compounds were determined on the basis of their 1D NMR, 2D NMR and HRMS spectral data. Their inhibitory effects on rabbit platelet aggregation respectively induced by PAF, AA and APD were tested. Weak to moderate inhibitory activities for each compound were observed.