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Communication | Regular issue | Vol 65, No. 6, 2005, pp.1283-1287
Published online, 19th April, 2005
DOI: 10.3987/COM-05-10377
Cross-Metathesis Reaction of 1-Allylated β-Carboline and Isoquinoline Derivatives

Kazuhiro Nagata, Takashi Itoh, Hiromi Fukuoka, Shigeru Nakamura, and Akio Ohsawa*

*School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan

Abstract

N-Protected 1-allyl-1,2,3,4-tetrahydro-β-carboline and 1-allyl-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline were subjected to the cross-metathesis reaction with functionalized olefins using second-generation Grubbs catalyst. The products were obtained in moderate to good yield with high (E)-selectivity.