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Note | Regular issue | Vol 65, No. 8, 2005, pp.1931-1938
Published online, 7th June, 2005
DOI: 10.3987/COM-05-10378
The Library of Cinchona Alkaloids-1,2,3-triazole Derivatives: Structure and Facile Access by “Click Chemistry

Karol Kacprzak,* Michal Migas, Agnieszka Plutecka, Urszula Rychlewska, and Jacek Gawronski

*Department of Chemistry, Adam Mickiewicz University, ul. Grunwaldzka 6, 60-780 Poznán, Poland


New Cinchona alkaloids-1,2,3-triazole derivatives library was prepared readily and efficiently using Huisgen 1,3-dipolar cycloaddition of 9-azido substituted Cinchona alkaloids and various terminal and disubstituted alkynes (click chemistry). Spectroscopic, X-Ray, and molecular modelling data show that these derivatives maintain the conformation of the parent alkaloids.