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■ An Efficient Synthesis of Bergapten

Kazuaki Oda,* Naozumi Nishizono, Yukio Tamai, Yuki Yamaguchi, Teruki Yoshimura, Keiji Wada, and Minoru Machida

*Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan

Abstract

An efficient synthesis of the linear furanocoumarin, bergapten, is reported. In order to avoid the formation of the angular furanocoumarin, we have adopted iodine as protecting group at the 8 position of the coumarin ring.