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Note | Regular issue | Vol 65, No. 10, 2005, pp.2483-2492
Published online, 12th August, 2005
DOI: 10.3987/COM-05-10484
A Simple Method for the Synthesis of 1-Substituted β-Carboline Derivatives from Tryptamine and Carboxylic Acids in Polyphosphoric Acid

Iliyan Ivanov,* Stoyanka Nikolova, and Stela Statkova-Abeghe

*Department of Organic Chemistry, University of Plovdiv, 24, Tsar Assen Str. 4000 Plovdiv, Bulgaria

Abstract

A number of 1-substituted 3,4-dihydro-9H-β-carboline derivatives (4) with high purity and yields have been synthesized by treating of tryptamine (1) with carboxylic acids (2) in polyphosphoric acid. 3,4-Dihydro-9H-β-carbolines (4) were successfully transformed to 1,2,3,4-tetrahydro-9H-β-carbolines (5) and 9H-β-carbolines (6).