Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 65, No. 10, 2005, pp.2431-2439
Published online, 12th August, 2005
DOI: 10.3987/COM-05-10501
Isolation, Synthesis and Biological Activity of Grifolic Acid Derivatives from the Inedible Mushroom Albatrellus dispansus

Toshihiro Hashimoto, Dang Ngoc Quang, Makiko Nukada, and Yoshinori Asakawa*

*Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 180 Nishihamabouji, Yamashiro-machi, Tokushima, 770-8514, Japan


Grifolin, grifolic acid, grifolic acid methyl ester and a new compound grifolinol were isolated from methanolic extract of the inedible mushroom Albatrellus dispansus (Scutigeraceae). Their structures were established by a combination of 2D NMR, MS spectrum and chemical reaction. In addition, (+)- and (-)-daurichromenic acids were obtained by cyclization of grifolic acid. The inhibitory activity of TNF-α, anti HIV and antimicrobial activity of grifolic acid derivatives were examined.