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Note | Regular issue | Vol 68, No. 1, 2006, pp.137-149
Published online, 1st November, 2005
DOI: 10.3987/COM-05-10525
Convenient Synthesis and Physicochemical Profile of New Derivatives of Pyrimidine

Joanna Cabaj, Jacek Doskocz, Jadwiga Soloducho,* and Antoni Chyla

*Institute of Organic Chemistry, Biochemistry and Biotechnology, Wroclaw University of Technology, Wyb. Wyspianskigo 27, 50-370 Wroclaw, Poland

Abstract

A synthesis of linear oligoheterocycles based on the substituted pyrimidines are described. The desired compounds have been accomplished by the variation of the original Pinner synthesis in which the aliphatic nitrile reacted with hydrogen chloride to give imino ester. These compound reacted with ammonia gas to give amidine. Chalcones in reaction with amidines give bis(phenyl)pyrimidines. The bis(phenyl)pyrimidines reacted with 3,4-ethylenedioxy-2-trimethyltinthiophene or 2-trimethyltinthiophene in the presence of Pd(PPh3)2Cl2 or Pd(PPh3)4 as catalyst to give designed compounds. In this work are presented also some electrochemical measurements using Langmuir - Blodgett technique in mono- and binary systems.