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Paper | Regular issue | Vol 65, No. 12, 2005, pp.2885-2892
Published online, 22nd September, 2005
DOI: 10.3987/COM-05-10527
Synthesis of Functionalized 5,5-Disubstituted Isoxazolines via 1,3-Dipolar Cycloaddition Reactions of Geminal Disubstituted Alkenes

Ashton T. Hamme, II,* Jianping Xu, Jun Wang, Tiffany Cook, and Erick Ellis

*Department of Chemistry, Jackson State University, Jackson, Mississippi 39217, U.S.A.

Abstract

Regioselective syntheses of functionalized 5,5-disubstituted 2-isoxazolines were achieved through 1,3-dipolar cycloaddition reactions of various aromatic nitrile oxides with geminal disubstituted alkenes.