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Note | Regular issue | Vol 65, No. 12, 2005, pp.2979-2989
Published online, 14th October, 2005
DOI: 10.3987/COM-05-10548
An Efficient Synthetic Route to New Imidazo[1,2-a]pyridines by Cross-Coupling Reactions in Aqueous Medium

Caroline Castera, Maxime D. Crozet, and Patrice Vanelle*

*Laboratory of Pharmaceutical Organic Chemistry (LCOP), UMR CNRS 6517, University of the Méditerranée , Faculty of Pharmacy, 27 Boulevard Jean Moulin, 13385 Marseille cedex 5, France

Abstract

The Suzuki cross-coupling reaction of 6-bromo-3-nitro-2-phenylsulfonylmethylimidazo[1,2-a]pyridine and 6-bromo-3-nitro-2-tosylmethylimidazo[1,2-a]pyridine provided an efficient route to the corresponding 6-aryl- 3-nitro-2-phenylsulfonylmethylimidazo[1,2-a]pyridines and 6-aryl-3-nitro- 2-tosylmethylimidazo[1,2-a]pyridines. The reaction was catalyzed by palladium(0) in aqueous medium.