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Paper | Regular issue | Vol 68, No. 2, 2006, pp.247-255
Published online, 13th December, 2005
DOI: 10.3987/COM-05-10591
Isolation, Structure Elucidation, and Syntheses of Isoneocryptotanshinone II and Tanshinlactone A from Salvia miltiorrhiza

Chang-Ming Sun, Tsung-Mei Chin, Yun-Lian Lin, Chien-Jui Chen, Wei-Chou Chen, Tian-Shung Wu, and Ming-Jaw Don

*National Research Institute of Chinese Medicine, 155-1, Sec. 2, Li-Nung Street, Taipei 112, Taiwan, R.O.C.

Abstract

Two new components, isoneocryptotanshinone II (1) and tanshinlactone A (2), were isolated from an EtOH extract of Salvia miltiorrhiza. The structures of 1 and 2 were established by spectroscopic methods and total syntheses. Compound (2) exhibited moderate cytotoxic activities with a CD50 range of 6.87-8.85 μg/mL against the HeLa (cervical epitheloid carcinoma), HepG2 (hepatocellular carcinoma) and OVCAR-3 (ovarian adenocarcinoma) cell lines.