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Note | Regular issue | Vol 68, No. 2, 2006, pp.339-345
Published online, 20th December, 2005
DOI: 10.3987/COM-05-10598
Two Isoquinolones from the Roots of Phellodendron amurense var. wilsonii

Yu-Lung Chiang, Chung-Ren Su, Ping-Chung Kuo, Amooru G. Damu, and Tian-Shung Wu*

*Department of Chemistry, National Cheng Kung University, 1, Ta-Shiueh Rd., Tainan, 70101, Taiwan, R.O.C.


Two isoquinolones, anhydroberberillic acid (1) and methyl anhydroberberillate (2) were isolated first time from the roots of Phellodendron amurense var. wilsonii as well as two related known compounds, berberine (3) and 8-oxyberberine (4). Their structures were elucidated by extensive 1D, 2D NMR and MS spectral analysis. Occurrence of the isoquinolones and protoberberines in the same plant indicated the definite possibility of these metabolites biogenetically originated from berberine alkaloids.